Tolstikova K. Clinical and Laboratory Assessment of the Risk of Developing Food Allergy in Young Children on Baby-Led Weaning (BLW)

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0825U003981

Applicant for

Specialization

  • 228 - Педіатрія

Specialized Academic Board

PhD 253

Shupyk National Healthcare University of Ukraine

Essay

The dissertation is devoted to the optimization of the dietary regimen for children at risk of developing food allergies based on the analysis of physical development indicators, levels of trace elements, total protein, and allergic status in different groups of infants and young children who are fed using the Baby-Led Weaning (BLW) method. "Complementary feeding is not just about food it's about relationships, trust, development, and lifelong health," said Berthold Koletzko, President of the European Academy of Paediatrics (EAP), at the PRIME PEDIATRICS 2025 Congress in Lviv. In the 21st century, perspectives on introducing solid foods to infants through complementary feeding have evolved. Since the early 2000s, an alternative method known as Baby-Led Weaning (BLW) has emerged and gained popularity. The potential advantages and drawbacks of BLW particularly its impact on child growth and development, as well as the intake of adequate age-appropriate macro- and micronutrients have become the subject of ongoing debate. Questions also remain open regarding how different types of complementary feeding influence the development of food allergies (FA). The aim of this study was to comprehensively assess the levels of food sensitization, physical development status, and the characteristics of micronutrient and protein absorption in young children following the BLW (Baby-Led Weaning) approach, with subsequent scientific justification and implementation of recommendations for optimizing nutrition in children belonging to various risk groups for developing food allergies. 11 Based on a specially developed questionnaire, a survey was conducted among 545 Ukrainian mothers, and 502 informative responses were analyzed. It was found that the largest proportion of modern mothers preferred BLW feeding – 204 (40.6%), 186 (37.0%) followed traditional spoon-feeding, and 112 (22.3%) used a mixed type of complementary feeding. In 82.5% of cases, mothers obtained information about BLW independently through books and internet resources, and much less frequently through doctors’ recommendations (8.60%) or their social circle (8.90%). It was established that the vast majority of mothers who chose BLW (98.0%) offered their infants food in a safe form, and only 1.5% offered adult food directly from the family table without modification. Typical features of Ukrainian mothers who practiced BLW were a normosthenic body type (80.4%), higher education (91.7%), urban residency (85.8%), and more than half (65.7%) were on maternity leave. In families practicing BLW, the child was most often the firstborn (75.5%). Depending on the method of complementary feeding, the respondents were divided into 3 groups: Group 1 – BLW feeding (204 participants), Group 2 – traditional spoon-feeding (186 participants), Group 3 – mixed feeding type (112 participants). For the purpose of analyzing anamnesis data and assessing laboratory parameters and overall physical development in children on different types of complementary feeding, 100 children were examined. The participants were divided into three groups according to the type of complementary feeding: children following a BLW (Baby-Led Weaning) approach (n = 40); children receiving traditional feeding (n = 30); and children receiving mixed feeding (n = 30). A comparative analysis of information about the children showed that birth data were generally similar across the three groups: most were born full-term (95.9%), predominantly via spontaneous delivery (70.9%), with average birth weight (3384±501 g) and length (53.6±4.17 cm); 87.2% of infants were exclusively breastfed before complementary feeding was introduced. The duration of breastfeeding was significantly shorter in the traditional feeding group compared to the BLW group (p=0.0004) and the mixed feeding group (p=0.0001). The age at which complementary feeding was introduced was significantly lower in the traditional feeding group compared to the BLW (p=0.0005) and mixed feeding groups (p=0.0003). Among adverse events, 12 regurgitation was more frequent (40.9%, p=0.012) in the traditional feeding group, while gagging/choking on food occurred more often in the BLW group (11.8%, p=0.043). Clinical and anamnesis-based assessments of atopy in infants in the three groups showed no significant differences overall, though atopic manifestations were more common (9.82%) in the mixed feeding group, along with a complicated family history of atopy (50.9%). A comparative analysis of physical and cognitive development, hematological parameters, and macro- and micronutrient levels after 6 months of complementary feeding was carried out in 3 groups: Group 1 – children fed with BLW (40 participants); Group 2 – traditional feeding (30 participants); Group 3 – mixed feeding (30 participants).

Research papers

Таршина К.І., Шарікадзе О.В. Порівняльний аналіз показників мікронутрієнтів і білкового обміну у дітей на різних видах прикорму. Імунологія та Алергологія: наука і практика. 2024; 2: 38-46. DOI: https://doi.org/10.37321//immunology.2024.2-05 https://immunology.org.ua/index.php/journal/issue/view/18/2-2024-pdf Ключові слова: BLW-прикорм, залізодефіцитна анемія, мікронутрієнти, білковий обмін

Таршина К.І., Шарікадзе О.В Дослідження поширеності BLW прикорму серед українських матерів із немовлятами після 6-місячного віку. Проблеми клінічної педіатрії. 2024; 1(63) : 8-13. DOI 10.24144 / 1998-6475.2024.63.8-13 https://dspace.uzhnu.edu.ua/server/api/core/bitstreams/cf26b088-314b-4cbc-a88f-114781bf6c29/content https://dspace.uzhnu.edu.ua/jspui/handle/lib/67106. Ключові слова: : BLW прикорм, харчування, грудне вигодовування, грудний вік, анкетування

Таршина К.І., Шарікадзе О.В., Зубченко С.О. Особливості введення прикорму серед українських немовлят після 6-ти місячного віку. Modern pediatrics. Ukraine 2024; 3(139) : 46-54. DOI:https://doi.org/10.15574/SP.2024.139.46 http://mpu.med-expert.com.ua/article/view/307347/298862 Ключові слова: немовлята, грудне вигодовування, прикорм, Baby-Led Weaning https://www.scopus.com/pages/publications/85198479066

Таршина К.І., Шарікадзе О.В., Зубченко С.О. Особливості сенсибілізації харчовими алергенами дітей, які знаходились на BLW прикормі. Вісник Харківського національного університету імені Каразіна. Серія Медицина, 2025; 33(1(52)):48-58. DOI: https://doi.org/10.26565/2313-6693-2025-52-04. https://ukrmedsci.com/index.php/visnyk/article/view/138/132 Ключові слова: Baby-led weaning, види прикорму, сенсибілізація, харчова алергія, атопічний дерматит https://www.scopus.com/pages/publications/105004811692

Таршина К.І., Шарікадзе О.В., Зубченко С.О. Асоціативні взаємозв’язки рівнів мікро- та мікронутрієнтів у дітей з атопічним дерматитом на BLW прикормі. Modern Pediatrics. Ukraine. 2025; 2(146): 20-25 DOI: 10.15574/SP.2025.2(146).2025 https://med-expert.com.ua/journals/wp-content/uploads/2025/06/05.pdf Ключові слова: baby-led weaning, атопічний дерматит, макронутрієнти, мікронутрієнти, діти Scopus https://www.scopus.com/pages/publications/105008275179

Таршина К.І., Шарікадзе О.В., Зубченко С.О. Aтопічний дерматит і введення в раціон дитини твердої їжі за методом BLW: чи існує асоціативний зв'язок? Праці Наукового товариства ім. Шевченка. Медичні науки. 2025; 1 (77): 1-9 DOI:https://doi.org/10.25040/ntsh DOI: https://doi.org/10.25040/ntsh2025.01.14 https://mspsss.org.ua/index.php/journal/article/view/1182/894 Ключові слова: Baby-led weaning, види підгодовування, прикорм, атопічний дерматит, харчова алергія Scopus https://www.scopus.com/pages/publications/105013592176

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