Boysak I. The state of the hepatobiliary system and mechanisms of formation of changes in children with ARVI, ways of correction

The dissertation is devoted to the study of the state of the hepatobiliary system and the formation of functional changes in children with ARVI, as well as the evaluation of the effectiveness of the developed optimized therapy. A clinical and laboratory examination was carried out in 115 children aged 6 to 8 years (average age 6.31 ± 0.47 years). The microbiological spectrum was dominated by Adenovirus (26%), Parainfluenza (22%), and Rhinovirus (16%). Patients were divided into two groups: the 1st group (n=60) received optimized treatment including a vitamin-mineral complex (Vitamin D3, Zinc, Ascorbic acid) and Methionine, while the 2nd group (n=55) followed standardized protocols. The control group consisted of 26 healthy children. The results showed that gastrointestinal symptoms such as nausea (n=37), abdominal pain (n=25), and diarrhea frequently accompanied respiratory signs. Objective findings included tongue tightness (82.8%) and pale skin. Optimized therapy significantly accelerated recovery (by 1.9 days) and the convalescence period (by 9.0 days). Ultrasound examination revealed that gallbladder functional disorders were present in 70.0% of children, with the hypomotor type being the most common (60.0%). Laboratory monitoring confirmed a significant increase in Zinc and Vitamin D3 levels, and normalization of bilirubin and total protein in the optimized therapy group. The scientific novelty includes the clarification of the dynamic clinical analysis of hepatobiliary dysfunction during ARVI and the establishment of changes in the enzymatic and hormonal links (Аmylase, Lipase, Gastrin). Mathematical models were developed to predict the dynamics of Vitamin D3, Cholecystokinin, and Bile acids. The practical significance lies in the recommendation of Gallbladder ultrasound and the use of the developed optimized therapy for one month to prevent functional disorders. Key words: acute respiratory viral infections, course, clinical and laboratory examination, vitamin and mineral homeostasis, components of the enzymatic and hormonal link of the digestive tract functional state, amino acid spectrum, ultrasound examination, children.