Puskov V. Scaled-up semi-industrial synthesis of benzannelated azoles.

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0826U004968

Thesis Registration Form

0826U004968.pdf

Applicant for

Specialization

  • 102 - Хімія

04-09-2026

Specialized Academic Board

PhD 16670

Taras Shevchenko National University of Kyiv

Essay

Heterocyclic compounds occupy a central position in modern organic, medicinal, and materials chemistry, since heteroaromatic fragments often determine the biological activity, molecular-recognition, physical properties, and practical applicability of organic molecules as functional materials. Among numerous classes of heterocycles, benzo-fused azoles, in particular benzothiazoles and benzimidazoles, are of special importance. These structural motifs are found in pharmaceuticals, biologically active compounds, fluorescent dyes, sensor molecules, optoelectronic materials, and intermediates for fine organic synthesis. The combination of aromatic nature, the presence of heteroatoms, and the possibility of functionalization at different positions makes benzazole systems convenient platforms for the design of compounds with predefined properties.

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Research papers

Puskov, V. O.; Babii, S. B.; Adamenko, I. V.; Melnychuk, S. O.; Druzhenko, T. V.; Lyapunov, A. Y.; Popov, S. V.; Volochnyuk, D. M.; Ryabukhin, S. V. Practical OnePot Synthesis of 2-Alkyl-Substituted Benzothiazoles from Bis(2-nitrophenyl)- disulfides. Org. Process Res. Dev. 2024, 28 (12), 4273–4280.

Puskov, V. O.; Lyapunov, A. Yu. Cyclic Voltammetric Profiling of Bis(2- nitrophenyl)Disulfides in a Benzothiazole Precursor Series. Journal of Organic and Pharmaceutical Chemistry 2026, 24 (2), 21 – 26.

Puskov V.; Babii, S.; Adamenko, I.; Melnychuk, S.; Druzhenko, T.; Lyapunov, A.; Popov, S.; Volochnyuk, D.; Ryabukhin, S. Single-step semi-industrial synthesis of 2-alkyl-substituted benzothiazoles. ACS Spring 2023, March 26-30, 2023, Indianapolis, Indiana, USA.

Puskov V.; Babii, S.; Lyapunov, A.; Volochnyuk, D.; Ryabukhin, S. One-step scalable access to benzo-fused imidazoles and oxazoles: A cost-effective and ecofriendly approach. ACS Fall 2025, August 17-21, 2025, Washington, D.C., USA.

Puskov V.; Babii, S.; Lyapunov, A.; Druzhenko, T.; Volochnyuk, D.; Ryabukhin, S. New frontiers in the multigram synthesis of benzo- and heteroannelated 1,3-azoles. ACS Spring 2026, March 22-26, 2026, Atlanta, Georgia, USA

Puskov, V. O.; Babii, S. B. Druzhenko, T. V.; Lyapunov, A. Yu.; Volochnyuk, D. M.; Ryabukhin, S. V. Direct green synthesis of benzimidazoles from orthonitroanilines, ortho-dinitroanilines and carboxylic acids promoted by sulfur oxo salts. ChemRxiv 2026, 2026

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Files

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