Korol'chuk V. Localization of plasminogen binding sites on streptokinase

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0400U000818

Thesis Registration Form

0400U000818.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

29-03-2000

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

Streptokinase, human plasminogen, antibodies. The localization of plasminogen binding sites and epitopes of human antistreptokinase antibodies on streptokinase primary structure. Chromatography , electrophoresis, determination of enzymatic activity, ELISA, Western blotting. It was localised 11 plasminogen binding sites on streptokinase. It was proven interaction of streptokinase C-terminal domain sequence T361-R372 with plasminogen sequence V709-E724. It was localised linear epitopes of antistreptokinase antibodies. Ten of them overlapped with plasminogen binding sites. Field of application - scientific institutions of medical and biological type.

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