Koval's'ka V. Peculiarities of interaction of monomethyne benzothiazole cyanine dyes with DNA: study by spectral-luminescent methods

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0400U001038

Thesis Registration Form

0400U001038.pdf

Applicant for

Specialization

  • 03.00.03 - Молекулярна біологія

18-04-2000

Specialized Academic Board

Д26.237.01

Essay

Features of monomethyne benzothiazole cyanine dye interactions with DNA were studied using various spectral-luminescent methods. Based on experimental results "half-intercalation" model of monomethyne cyanines - DNA interaction was proposed. The influence of organic solvent on spectral-luminescent properties of the dye - DNA complexes was studied for the first time. The influence of aggregation processes in water solutions of cyanines on structure and spectral luminescent properties of dye-DNA complexes were investigated. It was shown that the monomethyne cyanines Cyan 13 and Cyan 40 can serve as fluorescent probes for nucleic acids detection.The branch of application- molecular biology.

Read more

Files

disser full text.doc

Similar theses

0423U100120

Bondarchuk Tetyana V.

The human translation elongation complex eEF1B: structural organization and functional features

0421U103927

Rodriguez Ruslan Reynaldovych

Molecular features of folate-dependent metabolism in the human placenta are normal, in hyperhomocysteinemia and depending on the polymorphism of the methylenetetrahydrofolate reductase gene in in vivo, ex vivo and in silico studies.

0421U102070

Mankovska Oksana S.

Epigenetic and expression markers of the cancers of genitourinary system

0421U101905

Protopopov Mykola

Development of bioavailable protein kinase CK2 inhibitors

0421U101894

Marchyshak Tetiana

Hepatoprotective effect of oligoribonucleotide complex with D-mannitol in thioacetamide-induced hepatotoxicity in experimental animal models