Makhnevych T. The biochemical mechanisms of increased platelet sensitivity towards thrombin under insulin dependent diabetes mellitus

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0400U001664

Thesis Registration Form

0400U001664.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

20-06-2000

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

Human and rat platelets suffering from insulin dependent diabetes mellitus. Tyrosine specific phosphorylation, activity of antioxidant enzyme activities, nicotinamide influence on platelet aggregation under diabetes. Determination of the enzyme activity, Western blotting, electrophoresis. It was shown increased phosphorylation on tyrosine, dynamics and mechanism of c-Src and p85a translocation into cytoskeleton of diabetic platelets. Nicotinamide administration normalizes diabetic platelet aggregation. Field of application - scientific institutions of medical and biological type.

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