Matyukha M. Diagnostic meaning of parameters of a functional condition of the peripheral blood neutrophyls in pacients with rheumatic diseases and symptomatic leukopenia.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0401U001539

Applicant for

Specialization

  • 14.01.12 - Ревматологія

15-05-2001

Specialized Academic Board

Д 26.616.01

State Institution National Scientific Center "The M.D. Strazhesko Institute of Cardiology National Academy of Medical Sciences of Ukraine"

Essay

On the basis of perennial observation the selection and ordering of parameters which were the most informative for displaying of the dependence of frequency of infectiouse complications on decrease of neutrophils number, their functional reserve and activity of inflammatory process was carried out. As a result of the researches the most informative differential diagnostic criteria, which were useful for a prevention and diagnostics of infectiouse complications with formation of the increased risk groups and realization well-timed treatment were revealed. The practical value had the determination of patients with low parameters of the neutrophils functional reserve from general population of patients, as the risk-group in order to make early prognosis of the clinical course of purulent - inflammatory complications. As it was shown in work, in 29,85 % of patients with rheumatism, in 33,3 % with RA and in 67,16 % with SLE there were serious bacterial complications, which made the clinical course of main p rocess significantly worse and were the cause of lethal outcomes.

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