Garifulin O. Identification of gene complexes with altered normal expression in astrocytic gliomas

The data on participation in carcinogenesis of malignant astrocytic gliomas have been obtained for about 1% of genes that are expressed in human brain cells. The 4-fold decrease of RNA quantity in astrocytic tumor sample was determined as normalized with human brain RNA sample for proper northern-analysis of genes expression. For 203 identified genes with documented function were determined the groups that could be involved in astrocyte malignant transformation processes. The activation of normally repressed Sox-2 gene was revealed prevalently in gliomas that could determine the expression of genes with activity only in proliferous embryonic neural cells of these tumors. The prominent expression level of normally repressed HC gp-39 gene was revealed only in glioblastoma, that makes a possibility to use it as a molecular marker for these tumors.