Pirozhkova-Patalakh I. Antioxidative and anticarcinogenic activity of cluster compounds of rhenium

The object of study: Donors and patients' human blood, rabbits, rats, mouse. The aim of study: to find out features of influence of cluster rhenium compounds on antioxidative indexes of blood in vitro, to investigate their activity on models of hemocatheretic anemia and tumour growth. Methods and equipment: SOD, katalase, glucoseoxidase activity, MDA and aminic nitrogen level determination, morphological investigations, method of spontaneous, acid and free-radical hemolysis, lead-acetate and phenyl-hydrazine anemia, tumour growth models, toxicity determination; spectrophotometer, photoelectrocalorimeter, microscope.Theoretical and practical results, newness: binuclear cluster compounds retard hemolysis of erythrocytes, activate the glucoseoxidase-peroxidase system, correct antioxidative defence system indexes of blood in vitro and in vivo, inhibit growth of the Guerink carcinoma, have low toxicity. The sphere of application: biochemistry of biological active substances, bioinorganic chemistry, pharmaco logical biochemistry and toxicology.