GRIZhANOVA L. Risk factors, prognostic criteria and perinatal prophylaxis of intraventricular hemorrhages in underweight newborns

The work has studied the peculiarities of the clinical course of intraventricular hemorrhage (IVH) in underweight newborns associated with unfavorable factors of ante-and intranatal periods. There were evaluated prognostic significance of the combined gestosis of the pregnant women, nephropathies of the severe degree, winding of the umbilical cord round the neck, premature detachment of the normally located placenta, precipitated labor, drug stimulation of labor, labor in non-medical institution as causes, of occurrence and development of severe intraventricular hemorrhages. There are presented data about blood antioxidant system, intensity of tree-radical oxidation of lipids, anaerobic glicolysis in underweight newborns with IVH of I-IV degree. There was established high informative value of the level of lactic acid concentration in blood for prognosis of occurrence and development of severe IVH. There was worked out the scheme of perinatal prophylaxis of IVH in underweight newborns by using phenobarb italum. There was established effectiveness and safety of using phenobarbitalum in antenatal period in mothers and early neonatal period in babies. The work has studied the peculiarities of the clinical course of intraventricular hemorrhage (IVH) in underweight newborns associated with unfavorable factors of ante-and intranatal periods. There were evaluated prognostic significance of the combined gestosis of the pregnant women, nephropathies of the severe degree, winding of the umbilical cord round the neck, premature detachment of the normally located placenta, precipitated labor, drug stimulation of labor, labor in non-medical institution as causes, of occurrence and development of severe intraventricular hemorrhages. There are presented data about blood antioxidant system, intensity of tree-radical oxidation of lipids, anaerobic glicolysis in underweight newborns with IVH of I-IV degree. There was established high informative value of the level of lactic acid concentration in blood for prognosis of occurre nce and development of severe IVH. There was worked out the scheme of perinatal prophylaxis of IVH in underweight newborns by using phenobarbitalum. There was established effectiveness and safety of using phenobarbitalum in antenatal period in mothers and early neonatal period in babies.