Petrova Y. Polyreactive antibodies as regulators of adhesive interactions of cells

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0402U002748

Thesis Registration Form

0402U002748.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

23-09-2002

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

The object of investigation – polyreactive antibodies (Pab).The aim of work – to investigate immunochemical properties of Pab and to study their effect on cell adhesive interactions. Methods: ELISA, electrophoresis, immunoblotting, affinity chromatography, immunocytochemical staining, cell culturing, adhesion assay, phagokinetic migration assay. Polyreactive nature of 2C3 monoclonal antibodies was shown. It was found that Pab are able to modulate cell adhesion mainly at adhesive complex formation stage that leads to the increasing of cell migration activity. The results obtained can be used for the creation of antiinflammatory preparations. Field of application: scientific and educational institutes of medical and biological type.

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Files

Автореферат.doc

Диссертация.doc

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