Rud'ko N. Reductase activity of liver microsomes during stress in adult and old rats

The object of study: the antitoxic liver function, microsomal oxidationі Aim: to establish the age peculiarities of the change of microsomal reductase activity in the liver of adult and old rats during stressі Method of investigation: biochemicalі Results, novelty: it was found that on immobilization stress is not changed essential of NAD(P)H-depending reductase activity in liver microsomes of adult animalsі How ever took place declined in the concentration of NADPH and increased of reduced NAD part in a total pool of reduced pyridine coenzymes in liverі It was revealed that on stress in old rats decrease of reductase activity, declined in the concentration of NADPH and reduced NAD in liver in comparison with adult immobilized ratsі It is supposed that the revealed aging changes in microsomal reductase activity promote the decrease of reductase chain role in the process of microsomal oxidation and form the preconditions for antitoxic liver dysfunction at senescence under stressі Field of implementation: fundamental and clinical biochemicalі