Boyko M. Nitric oxide formation in rat's tissues during hypoxia and dipeptide carnosine insertion

The object - nitrosative stress at a hypoxia and action of histidine containing dipeptides; the aims - experimentally to confirm participation carnosine and Zn-carnosine during nitric oxide transformation; spectrometry, colorimetry, chromatography, biotesting, statistical methods; the new approach - carnosine and Zn-carnosine inhibit development of a nitrosative stress in olfactory bulb of a brain and blood of rats at an acute hypobaric hypoxia; the results - carnosine and Zn-carnosine improve conditions of a surviving of rats at a hypoxia, reduce the contents of lactate, nitrite- and nitrate-anions in olfactory bulb of a brain and blood of rats at a hypobaric hypoxia; the augmentation of nitrite reducing activity of deoxyhemoglobine is fixed at carnosine action in vitro; the binding carnosine with a haemoglobin is investigated; at such interaction the carnosine degradation does not descend; the main include methodical references - teaching on biological chemistry, subsequent researches with the purpose of development of drugs for the prevention of metabolic disorders at a hypoxia; the field - biological chemistry, pharmacology