Dzhuayeda M. Process of lipid piroxidation and antioxidation system under the influence of new derwatives of phenyloxaluric acid

The dissertation is devoted to determination of efficiency of carboxymethylamide of phenyloxaluric acid (CPA) and carboxymethylamide - 4 - ethoxyphenyloxaluric acid (C - 4-EPA) influence on the processes of lipid peroxidation, antioxidation system and some others in normal rats and at oxidation stress. CPA and C - 4 - EPA demonstrated antioxidant (antiinflammatory) properties. Which develop in the rats with oxidant stress in dynamics as decelerated lipid peroxidation processes; preserved reactions of antioxidant system, inhibition reactions of metabolic processes for amines, acutephase proteins, lipids and cytolysis enzymes. Antioxidation activity of CPA and C-4-EPA was approximately equal although some tendency to be more expressed in C-4-EPA. Both new substances at carragenine stress favour normalizing processes of lipid peroxidation, antioxidation system and others analogous to voltaren at less dose.