Kuchmenko O. Biochemical and functional properties of cardiomyocytes plasma membranes under oxidative stress and influence of active metabolite of vitamin E.

Object - plasma membranes of cardiomyocytes, erythrocytes and platelets. Purpose - to study the biochemical and functional properties of cardiomyocytes plasma membranes under the influence of stress-factors of different origin and active metabolite of vitamin E. Methods - experimental models of exposure of ionizing radiation, emotional-painful stress and hypercholesterolaemia, complex of biochemical and biophysical methods. The science novelty of thesis and conclusions: the development of oxidative stress in the plasma membranes of cardiomyocytes, erythrocytes and platelets forms the basis of stress-reaction following the influence of ionizing radiation, emotional-painful stress and hypercholesterolaemia; the real possibility of correction of changes and stabilization of lipid structure and functional condition of cardiomyocytes plasma membranes by supplementation of active metabolite of vitamin E was demonstrated. Field of applying - biochemistry.