Veklich T. Transport of Ca2+ in the smooth muscle cells mitochondria

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0403U001067

Thesis Registration Form

0403U001067.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

31-03-2003

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

Object of a research - Са2+-transport system of mitochondria of myocytes. The purpose - to study of the properties of Mg2+,ATP-dependent Са2+-transport system of mitochondria in smooth-muscle uterine cells. In the experiments using suspension of digitonin (0,1 mg/ml) treated myocytes we tested Mg2+,ATP-dependent Са2+-accumulation system as mitochondrial. It is sensitive to ruthenium red or sodium azide inhibition but resistant to thapsigargin or cyclopiasonium acid. Mitochondria transport system is specific to ATP and Mg2+. Cu2+ > Ni2+ > Co2+ are non specific to inhibit Mg2+,ATP-dependent Са2+-accumulation transport system іn mitochondria. Field of application: scientific institutes of medical and biological type

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Files

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