Rema S. Response of mast cells on extremely low frequency magnetic fields

The response of mast cells to the influence of magnetic field of different frequencies and amplitude was studied in vivo and in vitro. It was revealed that influence of complex spectra magnetic field results in the increase degranulation of rate in mast cells. The response of mast cell to the multiple magnetic field influence is weaker and connected with activation of adaptive system mechanisms. Influence of low frequency magnetic field results in the increase of spontaneous degranulation rate in mast cells in vitro. This increase depends on frequency, amplitude and exposure of magnetic field. Frequencies of 2; 8-10; 50; 72-74 Hz activate process of degranulation but, 32-34 Hz decrease spontaneous degranulation. The reaction of mast cells can be found with magnetic fields of very low amplitude - 50-200 nT. Dynamic changes of lipid peroxidation and lipid composition take place under the MF-induced degranulation. The reactions of mast cells to MF depend on concentration of calcium ions in the extracellular media. This dependence is nonmonotonous with maximum in 0,5 x 10-6 - 1,0 x 10-6 M/l. It was found that MF influence also modulate stimulative action of morphine and inhibitory action of sodium chromoglycate on mast cells. Mast cells as the element of diffuse endocrine systems (APUD- systems) and one of the receptors of magnetic field action and the starter phase of systems reactions in human and animals depending on the variation of electromagnetic background from natural and technical sources