Yahia B. Activity of the blood aminotransferases, phosphates and some oxidases in dynamics of new derivatives of oxanyl acid effect

The dissertation deals with determination of efficiency of the oxanyl acid ureid (UOA) and ureid-4-chloroxanyl acid (U-4-COA) in dynamics influencing on the activity of aminotransferases, phosphatases, oxidases and on the contents of some compounds in blood of white rats normally and at acute inflammation with oxida-tive stress. We have established that UOA and U4COA injected into healthy rats stomach in dosages of 50 and 100 mg/kg within 4 hours show no acceleration of metabolism of intracellular enzymes acute phase proteins, amines, lipids and lipid peroxidation, no depression of antioxidative system; at acute carragenine inflamation with oxida-tive stress demonstrate antiinflammatory, antioxidation properties influencing in dynamics on the decreasing in blood serum the indi-ces of alaninaminotranspherase, aspartataminotranspherase, alkali phosphatase, acid phosphatase, superoxiddysmutase, catalase, ceruloplasmin, histamine, serotonin, total proteins, fibrinogen, total lipids, cholesterol, deine conjugates, malone dialdehyde andreduced glutation