Podolnikova N. Identification and Characteristic of the Binding Sites for Platelet Integrins in the gамма C-Domain of Fibrinogen

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0404U001070

Thesis Registration Form

0404U001070.pdf

Applicant for

Podolnikova Nataliya Petrivna

Specialization

03.00.04 - Біохімія

Date of defense

22-03-2004

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

The object of investigation- gamma C domain of fibrinogen. The aim of work-to identify a sequence within gamma C, that mediates binding of fibrinogen and platelet integrins.Methods: fibrin clot retraction, platelet adhesion, peptide synthesis, synthesis of recombinant protein, chromatography. Gamma 370-383 (P3) is a new binding site for integrins alfa (IIb) beta (3) and alfa (5) beta (1) .There are 4 critical amino acid residues within P3 Lys 373, Arg 375, Lys 380, Lys 381. The site for integrin alfa (IIb) beta (3) in the gamma C domain of fibrinogen is complex and is formed by the gamma 408-411 and gamma 370-383. Field of application: design of new medications.

Thesis supervisor

Volkov Georgij Leonidovich

Official opponents

Козлов Едуард Андрійович
Євдокімова Наталія Юріївна

Files

PodolnikovaNew.doc

autorefbody.doc

avtoreCover.doc

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