Ignatenko N. Pathomorphological Scin Changes in Dogs with Demodecosis

The object - demodecosis in dogs. The aim - to study occurrence, pathogenesis, the clinico-morphological features of demodecosis in dogs and to develop an effective method of diagnosing. The methods - histological, histochemical, morphometric, epizootological, clinical, haematologic, bacteriological, surgical and statistical.The novelty - the first thorough study of pathomorphological skin changes in dogs with demodecosis using histological and histochemical methods. The study determined special features of localization of the agent, the histochemical and morphometric parameters of different layers of epidermis, derma and the appendages of the skin. On the basis of their analysis and comparison with the morphological and histochemical indices of the skin of clinically healthy dogs new data of the pathogenesis of this acarodermatosis was obtained. It is shown, that the agent of demodecosis spends its entire cycle of development in the hairfollicles and glands of the skin. The destruction of the skin iscaused by two mechanisms: by the autoimmune reaction of the skin and by the mechanical action of the mites. The epizootological studies showed that there is clear correlation between the occurrence of this acarodermatosis and the age and the breed of the dog but not between the seasons and the occurrence of the disease.The clinical studies indicate that dogs in large cities develop both localized and generalized forms of demodecosis. The thesis thoroughly describes the histological and histochemical structure of the skin ofclinically healthy dogs and determines the quantitative features of the cells which infiltrate the skin, studies the histochemical composition of each skin layer.The results of the studies are used in the scientific process and scientific research. Field - veterinary medicine.