Vasylyk N. Morphological and functional changes and adaptation and compensatory reaction in dogs' organism at dirofilariosis

The object - adaptative and compensative process in dogs caused by dirofilariosis.The aim - determine the role of aetiopathogenetical factors in development of structural and functional disorders in dogs organism caused by dirofilariosis depending on invasion intensity and development scientifically proved methods of diagnostics and treatment.Methods - haematological, biochemical, immunological, cytohistological, biotechnological, helmintolarvoscopy, helmintoscopy and statistical.Novelty - determined relation between character of disease course, pathological alterations at D.repens invasion and quantity of invasion elements in organism. Based on our research, microfilaria being a constant biological irritant in organism of definitive host cause changes quantative and qualitative indicators of blood, metabolism disorders, development of destructive and dystrophical processes in parenchymatous organs and immunological reactions. First time in Ukraine we indentified helmint species - Dirofilaria repens by means specific microfilaria smear on acid posphatase. Conducted experimental investigations proved ability tested mosquito species (An. m. atroparvus, C.p. molescus, Aedes aegypti L.) to be a intermediate host of nematoda D. repens in condition of Ukraine. Based on results, it is assumed that An. m. atroparvus is more appropriate for D.repens larva development by comparison with C.p. molescus and Aedes aegypti L. Based on own clinical observations it was defined asymptomatic and 4 main forms of dirofilariosis which were observed in spontaneously invased dogs by D.repens in Kyiv region: intoxication, skin, pseudotumor and heart-liver-kidney deficiency. It was gained positive results in trials of new local diagnostic kit for D. repens on determination residual quantity DNA of parasite in invased organism using PCR. High efficiency of proposed scheme usage of macro- and microfilaricidal medicines in combination with pathogenetical and homeopatic therapy for correction pathological changes at dogs dirofilariosis has been proved.The results of research - has been using in training process, scientific and research works.Branch - veterinary medicine.