Abdullach D. Structure functional characteristics of medium mass molecules in blood plasma of those people who suffer ischemic heart disease.

Object: Biohemical mechanisms of the pathogenesis of ishemic heard disease (IHD) and role of middle mass molecules (MMM) in the course of disease. Aim: to istablish the composition, the capacity of and functional properties of MMM in the plasma people with the IHD, and also their influence on nitrate reductase activity of hemoglobin. Methods: spectrophotometric, chromatographic, optical-luminescentic, x-ray, chemical, electrophoretic. Novelty: The number of pecularities of MMM in the ningidrine- positive fraction of MMM in people with IHD in comparisen to healthy people was revealed. In the spectrum of peptides of MMM the number of fractions under the IHD increseas. In the profile of MMM of ill people the major component, which initiates the increase of peptide material from the beginning of chromathography disappears. The MMM in blood of people with IHD by the opticalpecularities differs markedly from MMM of healthy donors. The results may be used in the clinical practice for the diagnostics and evaluation of system functional state of vital ensuring under the heard ishemia conditions. The data testify the regulatory role of MMM in the endogenic NO formation system by the activation of blood hemic component of NO cycle reductase chain: The results may be used in the educational processes in the I.Franco Lviv national university, in the scientifical investigations of the department of biooptic analysis of institute of physical optics.