Yusova O. Plasmin activity regulation by indirect plasminogen's activators

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0404U004464

Applicant for

Specialization

  • 03.00.04 - Біохімія

29-11-2004

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

The object of investigation is plasmin and complexes plasmin with strepkinase or monoclonal antibody IV-1c.The aim is investigation of plasmin activity regulation in complexes with plasminogen activators. Modulation of plasmin substrate specifity during plasmin-streptokinase and plasmin-antibody IV-1c complexes formation was studied. It has been determinated by biochemical methods,that the plasmin activity differs from activity of it's complexes with streptokinase and antibody IV-1c. Method for antistreptokinase antibodies in human blood serum determination was developed. Field of application: scientific and educational institutesof medical and biological type.

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