Pavichenko O. The erythrocyte antioxidant system and heme oxygenase activity in rat heart, vessels and lung under hemolytic anemia development

The object of study is heart, vessels, lung, erythrocytes. The aim of study is the investigation of both erythrocyte antioxidant system work and heme oxygenase activity in rat heart, vessels and lung under hemolytic anemia caused by cadmium chloride or phenylhydrazine. Methods - biochemical: enzyme activity determination, differential spectrophotometry, photocolorymetry. The development of cadmium hemolytic anemia was shown to accompanied by the heme oxygenase induction and the activation of free radical processes in rat heart, vessels and lung. It can be conditioned by the heme entering to the cells of these organs from bloodstream. The increasing of heme oxygenase activity under phenylhydrazine hemolytic anemia can be caused by both the activation of free radical oxidation in rat heart and vessels owing to hypoxia, and the heme content products accumulation in rat lung. The feild of application: scientific institution of biological and medical profile because the results of research can be used in the method development of cardiovascular system damages correction under hemolytic anemia; in educational process about biochemistry and pharmacology.