Mishchuk D. Ethanol influence on the properties of Na+,K+-ATPase of rat brain cortex

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U000334

Thesis Registration Form

0405U000334.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

24-01-2005

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

The object of investigation - microsomal fraction of rat brain cortex. The aim - to elucidate the character of ethanol membrane-acting effect in vitro on rat brain cortex Na+,K+-ATPase and to define the activity of this enzyme system in vivo under conditions of chronic ethanol consumption. Methods of preparative biochemistry, biochemical membranology, spectrophotometry, spectrofluorimetry. It is shown that Na+,K+-ATPase sensitivity to ethanol effect in vitro depends on the integrity of enzyme protein-lipid complex in membrane. In vivo experiments showed decrease of rat brain cortex Na+,K+-ATPase activity at 10th day of early postnatal alcoholization of infant rats and after long-term alcoholization of adult rats for 15 months. Field of application - research and educational institutions of medical and biological profile.

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Files

Dissertation Mishchuk.doc

Автореф-Міщук.doc

Автореф-тит.doc

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