Kozubenko N. Neurospecific proteins level changes under experiential somatogenic pain and pharmacocorrecion

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U001346

Thesis Registration Form

0405U001346.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

04-04-2005

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

The object of investigation - biochemical mechanisms of transduction and analysis of nociceptive stimulation. The aim - investigating the influence of experimental somatogenic post-operative pain for some neurospecific proteins level in the rat brain. Methods: brain tissues fractioning, ultracentrifugation, carbohydrat-ensime analysis and ELISA, electrophoresis, imunobloting. Results: showed proteins NCAM, S100?, GFAP level and changes of total heparansulfate- and hyaluronate-biding activate under experimental somatogenic postoperative pain and under agonist and antagonist NMDA receptors. Showed Ketanov using decreases postoperative hyperalgesia consequences. Field of application - medical-biological establishments.

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Files

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