Hirin S. State of the prooxidant-antioxidant system and induction of the chromosome aberrations under conditions of the xenobiotics action.

Object of research. Prooxidant-antioxidant processes and chromosomal aberration forming under xenobiotic's action. Aim of research. The aim of the work was the investigation of prooxidant-antioxidant processes intensity and chromosomal aberration induction under action on an organism of the most widespread xenobiotics in industrial regions. Methods of research. Biochemical, cytogenetical, statistical. Theoretical and practical results. The results of researches allows to deepen the knowledge's as to xenobiotic affect on prooxidant-antioxidant system of an organism action and on process of chromosomal aberration forming. The organism reaction on combine action of most widespread xenobiotics in industrial regions of Ukraine was determined. The dependence of antioxidant processes and lipid peroxidation with chromosomal aberrations forming on predictabilities of adaptational syndrome was found. The correlational connections between prooxidant-antioxidant system indexes and cytogenetical parameters were established. The indexes of antioxidant system state and intensity of lipid peroxidation process in an organism can be used as sensitive integral indexes of the degree of xenobiotic damage action. The researches and received correlational connections between prooxidant-antioxidant system indexes and cytogenetical parameters give possibility to explain the necessity of take measures for antioxidant prevent from chromosomal aberration forming. All of this permit to conduct genetic monitoring among population of Ukraine more quickly that have to promote to safe prevent its genofond. Degree of adoption. Methodical recommendations (to be prepared to printing). Field of application: biochemistry, physiology, genetics, ecology, medicine.