Linetska M. alpha-Latrotoxin as stimulator of neurosecretion: mechanisms of action

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U002330

Thesis Registration Form

0405U002330.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

07-06-2005

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

The object is rat brain synaptosomes. To investigate the mechanisms of neurotransmitter release from nerve terminals induced by alpha-latrotoxin from black widow spider venom in the presence and absence of extracellular Ca2+. Methods of preparative biochemistry, neurochemical membranology, radioisotopic. It was shown the participation of the two pools of GABA (vesicular and cytosolic) in the realisation of secretogenic action of a-latrotoxin. Toxin action is dependent on its concentration used: in high concentration it stimulated cytosolic GABA release much more effectively. For the first time the involvement of plasma membrane GABA transporter in latrotoxin-stimulated GABA release was demonstrated. Field: scientific and educational biological institutes

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Files

Autoreferat.doc

LinetskaDisertation-3.1.doc

LinetskaDisertation-3.2. .doc

LinetskaDisertation-3.3.doc

LinetskaDisertation-3.4-5.doc

LinetskaDisertation-Matherials.doc

LinetskaDisertation-References.doc

LinetskaDisertation-Vstup.doc

LinetskaDisertation-Vysnovk.doc

LinetskaDisertation-discussion.doc

OGLYAD LITERATURY-LTX.doc

OGLYAD LITERATURY-Oglyad Lit.doc

OGLYAD LITERATURY-endocytosis.doc

OGLYAD LITERATURY-ГАМК-transporter.doc

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