Fayerman A. The lung injury in patients with gout: diagnostics, pathogenesis, treatment (clinical experimental research work)

The object of study: patients with different clinic-laboratory course of gout and animals with experimental model of disease; the purpose - improvement of quality of early diagnostics of respiratory system injury and the determination of pathogenesis of lung pathology on basis of clinical experimental research work; the methods -clinical, biochemical, physico-chemical, instrumental, morphological, statistical; novelty - is for the first time determined nature of deposits of uric acid and morphological changes in alveoli, interalveolar spaces, bronchi and blood vessels, as well as their pathomorphosis under influence of allopurinol developed in animals with experimental gout, it is proved changes of bronchial air conduction and pulmonary haemodynamics in patients with gout with "clinically healthy lungs", intercoupling of such abnormalities with joint and kidney pathology, abnormalities of exchange of purines, it is determined changes of respiratory humid exhalation, physico-chemical characteristicsof expirates, pulmonary metabolism of system of NO, uricolisis and expiratory excretion of uric acid; results -is determined criterion, allowing to diagnose the pathology of the lungs on early stages of its development in patients with gout, rationally adjust the dose of used uricodepressive medicines, more safely value the condition of exchange of purines; it is introduced in practic of medical-preventive institutions of Donetsk and Lugansk regions, Poltava, Kharkiv, as well as in pedagogical process of Donetsk and Lugansk medical universities; the range of usage - medical-diagnostic process rheumatologic , pulmonologic, therapeutic in-patient departments, polyclinics