Peleshenko G. Human fibronectin fragments and their immunoglobulin-binding activity in norm and in inflammatory processes in connective tissue

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U003771

Thesis Registration Form

0405U003771.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

21-09-2005

Specialized Academic Board

Д 64.051.17

Essay

The object of study: the role of fibronectin in maintenance of protective reactions of organism. The aim of study: estimation of degree of fibronectin fragmentation, of its immunoglobulin-binding activity under norm and under inflammatory process in connective tissue of human being and substantiation on this base of role of separate fibronectin fragments in formation and elimination of immune complexes. Methods: affinity chromatography, SDS-PAAG, immunochemistry methods, immunologic methods. Theoretical and practical results, novelty: in acute and chronic inflammatory processes increases blood plasma fibronectin degradation and immunoglobulin-binding activity of lowmolecular fibronectin fragments. Fibronectin fragmentation influences the formation and elimination of immune comlexes and points to activation of different proteolytic enzymes. The sphere of application: fundamental and clinical biochemistry.

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