Tykhomyrov A. Characteristic of the glial intermediate filament protein from the rat brain under inluence of aluminum ions and ionizing irradiation

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U003772

Thesis Registration Form

0405U003772.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

21-09-2005

Specialized Academic Board

Д 64.051.17

Essay

The object of study: implication of astrocyte intermediate filament protein in glial response on exogenous CNS injury. The aim of study: analysis of polypeptide composition and content of filament and soluble forms of glial fibrillary acidic protein (GFAP) of the rat brain under influence of Al3+ ions, irradiation and CNS-protective treatment. Methods: photocolorimetric, spectrophotometric, electrophoretic, chromatographical, immunochemical; testing of animals by "open field". Al3+ ions and irradiation produced changes in quantitative ratio between soluble and filamentous GFAP polypeptides. It has been shown first that Al3+ ions induce reconstruction of astrocyte intermediate filaments by means of limited proteolysis of their protein. Pyracetam and vitamin E decrease level of astrocyte reactivity under influence of irradiation and Al3+ ions seen by prevention of GFAP degradation and accumulation. The spheres of application: scientific institutions of medical and biological type, delivering special disciplines.

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