Datsko O. Diagnostics, Pathogenesis and Treatment of Ophthalmopathies at Reactive Chlamydia Trachomatis Urogenital Spondylarthritis (Reiter's Disease)

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U003993

Applicant for

Specialization

  • 14.01.12 - Ревматологія

16-09-2005

Specialized Academic Board

Д 11.600.02

Essay

Object of research - patients with reactive urogenital Chlamydia trachomatis spondylarthritis (Reiter's disease) with a defeat of eyes; the purpose - improvement of quality of diagnostics and treatment of ophthalmopathies at reactive Chlamydia trachomatis spondylarthritis, definition of parts them pathogenesis; methods - clinicals, bacterioscopies, X-ray, instrumentals, biochemicals, immunologics, radioimmunoassaies, immune-enzymes, statisticals; the novelty - for the first time at Reiter's disease is determined interrelation of separate variants of ophthalmopathies with weight of a defeat of the musculoskeletal system, urogenitals, skin, internal and nervous system, the role of infringements of humoral and phagocytic parts of immunity, proinflammatory eicosanoids and metabolism of nitric oxide in pathogenesis of conjunctivitis and uveitis is proved, the factors are established which determine efficiency of treatment of ophthalmopathies at such category of the patients; results - the medical technologyoptimum varied of system treatment of conjunctivitis and uveitis is developed at Reiter's disease, and also criteria, which allow to predict the further course therapeutic of measures at the patients with reactive urogenital Chlamydia trachomatis spondylarthritis is introduced into practice of patient care and preventive establishments of. Donetsk, Lugansk, Poltava, in pedagogical process of Donetsk and Lugansk medical universities; area of use - treatment-and-diagnostic process of rheumatological and ophthalmologic hospitals, polyclinics, pedagogical process of medical educational institutions

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