Lutay N. Glycosylation of fibronectins and their biologycal activity in norm and under pathologycal condition

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U004445

Thesis Registration Form

0405U004445.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

02-11-2005

Specialized Academic Board

Д 64.051.17

Essay

The object of study: the modification of fibronectin carbohydrate component and the features of fibronectin expression during oncogenesis. The aim of study: determination of quantitative changes and glycosylation degree of plasma fibronectin as well as detection of the features of cell fibronectin expression in norm and neoplasia. Methods: rocket immunoelectrophoresis, affinity immunoelectrophoresis, radioimmunoassay, SDS-PAAG, immunoblot, immunohistochemistry. Theoretical and practical results, novelty: development of neoplasia is accompanied with decreasing of quantitative of plasma fibronectin Con-binding carbohydrate determinants as a result of its modification; proteolysis of plasma fibronectin and it's level reducing in blood plasma were observed. The content of cell fibronectin increases in the neoplastic tissues, where it has cytoplasmatic localization in the cells. Field of application: fundamental and clinical biochemistry.

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Diser-Висновки.doc

Diser-Вступ.doc

Diser-Розділ I.doc

Diser-Розділ II.doc

Diser-Розділ III.doc

Diser-Розділ IV.doc

Diser-Список літ.джерел.doc

Diser-Титульний аркуш, зміст.doc

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