Vdovenko N. Influence of the ATP-containing compounds at a prooxydant-antioxidant balance on conditions of intensive physical loads

Objects - prooxydant-antioxidant balance in conditions of the oxidizing stress caused by intensive physical loadings. Purpose - to determine prooxydant-antioxidant the status of an organism under condition of intensive physical loadings and its correction by АТP-containing connections (АТP, АТP-LОNG). Methods - biochemical, biophysical, pedagogical. Newness - in conditions in vitro is found out antioxidant activity АТP-LОNG, established membranotropic activity of АТP-containing connections on models of a monospherical membrane. In the experiments which have been carried out in conditions in vivo (on animals), infringements prooxydant-antioxidant imbalance under influence of the maximal physical loading are shown. The expediency of use АТP-LОNG in conditions intensive physical loadings (in particular, in practice of preparation of sportsmen of high qualification) is scientifically-grounded.Results - the opportunity of correction in conditions of intensive physical loadings is shown with help АТP-LОNG.As a result of the experimental maximal physical loading in rats, the prooxydant-antioxidant imbalance that is mostly seen in the cerebrum and myocardium tissues has been observed. Thus use АТP-LОNG before performance of the maximal physical loading interferes with accumulation of ТBA-active products and raises physical serviceability of animals. Circuits disposable and course application of preparation "АТP-LОNG" for increase of physical serviceability of sportsmen, acceleration of processes of restoration after significant training and competitive loadings are developed. Branches - sports medicine, military medicine, aerospace medicine.