Osyp Y. Influence of alkaloids and triterpens from celandine (Chelidonium majus L.) on proliferation and metabolitic activity of cells in vitro.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0406U001386

Thesis Registration Form

0406U001386.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

14-03-2006

Specialized Academic Board

Д 35.368.01

Institute of Animal Biology of NAAS

Essay

Object – cytotoxicity activity and metabolism of glucose in mammalian cells. Methods of investigation: biochemical, chemical, statistic. Newness: The effect of five individual alkaloids (i.e. sanguinarine, chelerythrine, chelidonine, coptisine, berberine) obtained from greater celandine roots on cytotoxicity activity, phagocytic activity and chemiluminescence intensity in neutrophile granulocytes from human peripheral blood has been investigated. The effect of these compounds on glucose utilization and lactate production of NK/Ly cells and physical-chemical characteristics of DNA has been investigated. Area of use – biology, biochemistry, medicine.

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