Zolotnitskaya O. Influence antiviral drugs on structure and function immunocompetent cells at rheumatoid arthritis patients

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0406U001453

Thesis Registration Form

0406U001453.pdf

Applicant for

Specialization

  • 14.01.12 - Ревматологія

28-03-2006

Specialized Academic Board

Д 26.616.01

State Institution National Scientific Center "The M.D. Strazhesko Institute of Cardiology National Academy of Medical Sciences of Ukraine"

Essay

The dissertation is devoted to the decision of n actual problem of modern rheumatology - to increase of efficiency of treatment of rheumatoid arthritis (RA) patients development of recommendations for inclusion in a medical complex of drugs with antiviral activity, in view of virology, immunologic and clinical results of research of patients. It was shown, that at complex therapy RA patients with virus infection which includes preparations alpha-interferon and cycloferonum, the clinical effect methotrexate (MT) is considerably improved due to influence on viruses, potentiations immunologic action of basis therapy. At inclusion acyclovir in treatment of patients by RA with a virus infection also observed increase of clinical efficiency MT, that is connected by high activity acyclovir to a virus infection at RA. But application of preparations alpha-interferon and acyclovir is limited by their high toxicity and the big frequency of by-effects.

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Files

Диссертация Золотницкой.doc

автореферат Золотницкая.doc

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