Fomina O. Activity of the ensymes of endogenous aldehydes utilization in oxidation-reduction reactions in rats of different ages during immobilization

The object of study: process of utilization of endogenous al-dehydes in oxidation-reduction reactions in the liver and skeletal muscle of rats in differents ontogenesis period during immobilization. The aim of study: investigation of age- and tissues-dependent changes in activity of enzymes of oxidation-reduction conversions of endogenous aldehydes, stady of regulation effects of free-radical oxidation reactions products on aldehyde reductase activity in the liver during immobiliza-tion. Methods: spectrophotometry, spectrofluorimetry, dif-ferential centrifugation. Theoretical and practical results, new-ness: investigations have shown that changes in activity of the enzymes of endogenous aldehydes utilization have an particu-lar role in modulation of resistence of the liver and skeletal muscle to stress damaging factors in definite ontogenesis peri-ods. The work has shown that products of free-radical oxida-tion reactions (hydrogen peroxide and propional aldehyde) have peculiarities of the regulation effects on aldehyde reduc-tase activity in the liver during immobilization. In this connec-tion, a great significance in an increase in the tissues resistance to the impact of free-radical stress damaging factors belongs to a direct stimulation of velocity of utilization carbonyl products of metabolism. The sphere of application: research of age-related pathology mechanism, lecture course of biochemistry, pathology.