Bakurova H. The glycolisis and nucleotides enzymes activity in patients of various age with peptic ulcer and stomach carcinoma

Investigation object: proliferation processes, the age-dependant nucleotide and carbohydrate metabolism peculiarities under stomach ulcer and cancer. The aim: to reveal changes of nucleotide and carbohydrate metabolism enzymes activity in patients of various ages with ulcerous disease (UD) and stomach cancer (SC). To establish the metabolic disorders which may help for neoplastic transformation. To produce recommendations concerning the choice of treatment tactic for patients with UD. The methods: biochemical's (the thymidine phosphorylase, adenosine deaminase (ADA), glucose-6-phosphat- and lactate dehydrogenase (LDG) activities was investigated in tissues and blood), statistics. Results, novelty of investigation: it was proved, that carbohydrate and nucleotide metabolism enzymes activity in patients with ulcer and accompanying development of precancerous changes is close to their activity under stomach cancer. This allows considering those patients as belonging to the group of higher oncological risk,especially after 40. The revealed erythrocyte metabolism disorders (decrease ADA, increase LDG) can promote the development of morphofunctional changes in red blood cells. Enzyme testes were proposed, which may be used when forming groups of higher oncological risk, when forecasting ulcer complications development. Degree of application: These findings are applied to educational process in department of biochemistry of Donetsk state medical university; in therapeutic clinic from Institute of Urgent and Reconstructive Surgery, Ukrainian Academy of Medical Sciences; to practice in Donetsk Regional Antitumoral Center. Area of application: medical biochemistry, Health Care.