Koval L. The effect of nicotine on functions of B lymphocyte-derived cells

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0406U002405

Thesis Registration Form

0406U002405.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

05-06-2006

Specialized Academic Board

Д 26.240.01

Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine

Essay

The object of investigation is nicotinic acetylcholine receptor. The aim is to investigate the molecular basis of nicotine effects on B lymphocyte-derived cells. Methods: cell culturing, ELISA and Cell-ELISA, flow cytometry, ELISpot assay. The presence of nAChR in B lymphocyte-derived cells was demonstrated. The pro-proliferative role of nicotine for B lymphocyte-derived cells is demonstrated. The data obtained helps to explain the molecular basis of lymphoproliferative states accompanied with the decrease of serum immunoglobulin levels observed in tobacco smokers. Field of application: scientific and educational institutes of medical and biological type.

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Files

Автореферат.doc

Дисертація.doc

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