Slipaniuk O. Features of antioxidant system in the cows in late gestation and in newborn calves and some factors of its regulation.

Object – biochemical adaptation of metabolism in organism of cows in late gestation and in newborn calves. Aim – to study the intensity of peroxidative oxidation of lipids and activity of antioxidant defense system in highpregnant cows and newborn calves, the connention of these processes with carbohydrate and mineral metabolism and elaborate the means of its correction by antioxidants and trace elements. Methods of investigation and equipment - biochemical and statistic methods of determinaton of content of some components of peroxidative oxidation and activity of antioxidant defence enzymes. Novelty: The results obtained widen the data of literature about the peculiarities of metabolism in the organism of highpregnant cows, newborn calves and in placenta. It was established the increase of peroxidative processes and decrease of antioxidant enzymes activity sn the cows organism in the last month of gestation. The inhibitory effect of vitamin E and selenium on the intensity of peroxidative oxidation oflipids in the organism of highpregnant cows was revealed. The optimal oral dozes of vitamin E for the cows in late gestation were established. It was shown the inhibitory influence of insulin and chromium (III) on intensity of peroxidative oxidation of lipids in highpregnantt cows and their synergic effect on these processes. The increase of superoxide dismutase activity and decrease of peroxidative products in the blood of highpregnant cows after the addition of copper, zinc and manganese to their ration were established. Area of use – biochemistry, livestock, elaboration of correction of metabolic disturbances methods in late gestation of animals.