Utko N. mRNA content, key antioxidant enzyme activity and rate of gaseous exchange in aging drosophila, mice and rats

The object of investigation is mRNA content and activities of key antioxidant enzymes and gaseous exchange of lab insects and mammalians of different ages. The aim is to investigate of distribution types and correlative and cluster relations between indices, that characterizes mRNA content and key antioxidant enzymes activities, and gaseous ex-change of lab animals of different ages. Methods: polymerase chain reaction, spectrophotometric methods. For the first time have been established that the distribution of many of in-vestigated indices of young animals shows more wide diapason then old one. To reach old age mammals should keep the good correlation between antioxidant enzyme activities. The results of study can be used for design of tests, that characterize antioxidant defense effect at accelerated aging and pathologies.