Voroshylova N. The influence of an acid-alkaline condition on indicators of mineral exchange in organisms of rats of different age rats poisoned with cadmium

Dissertation is devoted to studying of the influence of acid-alkaline condition changes on contained cadmium and mineral exchange indicators in organisms of 3 month's, 6 month's and 18-month's poisoned rats. Biological models of introduction of different age groups rats in a metabolic acidosis and аlkalosis condition before and after poisoning with cadmium sulphate were developed, and acid-alkaline condition and mineral exchange indicators of the developed experimental models were investigated. It was found out that using of biological model of profound metabolic acidosis after poisoning with cadmium sulphate promotes reducing of cadmium content in blood, liver, kidneys, spleen, heart and lungs of different age poisoned rats, but it was found more cadmium in organisms of 3-month's rats. The influence of acid-alkaline condition changes in organisms on macroelements content in blood such as natrium, potassium, calcium, magnesium, inorganic phosphorus and microelements such as copper, zinc, iron in bloodand organs of poisoned rats according to the age aspect was investigated. Comparing biological models of acid-alkaline condition changes on organisms of poisoned animals, it was noticed that condition experimental metabolic acidosis in comparison with alkalosis after poisoning with cadmium sulphate is more effective in correction of cadmium intoxications and indicators normalization of mineral exchange in organisms of poisoned rats 3 month's and 6-month's rats.