Mohamad S. Age-related peculiarities in oxidative stress manifestation during hypothyroidism at rest and during exercise.

The object of study. Free radical processes and the first line antioxidant defense enzymes state in liver during experimental hypothyroidism of differently aged rats in norm and during exercises. The aim of study. Analysis of free radical protein oxidation and lipid peroxidation, activity of the first line antioxidant defense enzymes in liver of 1,5- and 12-months old rats during experimental hypothyroidism and during exercise as well. Methods. Spectrophotometry, spectrofluorimetry, differential centrifugation, immune-enzyme analysis, statistical analysis. Theoretical and practical results, newness. The results of the present study point out age depending peculiarities of change in free radical protein oxidation and lipid peroxidation state in liver of rats during hypothyroidism in puberty. Analysis of such peculiarities gives real preconditions to work out new differential approaches to hypothyroidism treatment in puberty and sexual maturity using antioxidant drugs, to its monitoring based on study offree radical protein oxidation and lipid peroxidation products content dynamics. For the first time age peculiarities in change of free radical protein oxidation and lipid peroxidation state in liver of rats during experimental hypothyroidism and exercises were studied. The sphere of application. Research of age-related pathology mechanism, lecture course of biochemistry.