Babych L. Blood and liver lipids and lipoproteins at ionizing irradiation and xenobiotics influence on organism.

The dissertation is devoted to theoretical substantiation and scientific problem solving that appears while determining biochemical breach ways in conditions of one-time or long-term influence of ionizing irradiation in the summary dose of 1,0 Gy, cadmium 1 mg/kg or karbendazim 750 mg/kg of mass and revealing the possibility of rates usage that have diagnostic significance for estimation of external factors influence on organism. Hepatotoxic effect of karbendazim and long-term cadmium has been revealed; it is being strengthened in conditions of combined with irradiation influence. It is determined that ionizing irradiation (while chronic influence) with increasing absorbed dose up to 1,0 Gy results in cholesterol, triacilglycerol and phospholipid content decrease; and combined influence of irradiation and investigated xenobiotics results in intensifying of revealed changes. The difference in blood serum lipoproteins redistribution is shown depending on external influence nature; and values oflipoproteins correlation may be used for characteristic of external factors influence on organism. The breaches in oxidative-antioxidant homeostasis are observed in conditions of all studied factors influence, both separate and combined. The analysis of biochemical blood indexes investigation in method of factor analysis indicates different manifestations (display) of organism reaction that we may group as following: as a result of one-time separate influence of irradiation, cadmium and karbendazim; of long-term influence of cadmium and irradiation; of combined influence of irradiation and cadmium or irradiation and karbendazim.