Miroshnychenko D. Structure and functions of GTPse modulating regions of Bcr protein in Ph'-positive leukemias

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0408U001886

Thesis Registration Form

0408U001886.pdf

Applicant for

Specialization

  • 03.00.03 - Молекулярна біологія

22-04-2008

Specialized Academic Board

Д26.237.01

Essay

The object is the biological role of DH and PH domains of Bcr and Bcr-Abl proteins in normal and malignant cells; the aim is functional characteristics of Bcr DH and PH domains and analysis of their role in signal pathways in PH'-positive leukemias; the methods are molecular biological methods including PCR, affinity chromatography, eukaryotic cell transformation, Western blot, fluorescent microscopy, MALDI TOF mass spectrometry; the novelty is identification of lipids and proteins that bind to Bcr PH domain, GEF activity of isolated Bcr DH domain was identified first time by pull down method, it was revealed that DH domain doesn't posses GEF activity against Rho GTPases RhoA, Cdc42 and Rac1 in vitro and in vivo; the field -molecular biology

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Files

AVTOREF.doc

AVTOREF.doc

Miroshnychenko-diss.doc

Miroshnychenko-diss.doc

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