Shyshkin M. Pathohistological and immunohistochemical peculiarities of progression of chronic viral hepatitis B and C according to data of liver's trepanobiopsies

Thesis contains the results of complex inspection of patients with chronic viral hepatitis B and C. There is conducted theoretic generalization and new salvation of scientific task, that consists of perfection of the most valuable microscopic criteria of progression of chronic viral hepatitis B and C according to data of liver's trepanobiopsies, and also definition of molecular- microscopic features, prognosing the development of liver fibrosis, in order to use this in diagnostic work and to optimize the treatment. There is estimated, that the degree of viral infection by hepatitis C virus is defined by immunohistochemical revealing of HBsAg and HBсAg. In order to define more precisely the activity's degree of chronic viral hepatitis, we can use immunohistochemical revealing of HBsAg in hepatocytes CD-8+Т-lymphocytes and CD-68+ Kupfer cells, for prognosing the possibility of development of severe liver's fibrosis, of А-SMA-positive Ito cells within perisinusoidal spaces of the liver, and also segmental collagenisation of walls of intralobular venous sinusoids