Babalyan Y. Cranioplasty of frontoorbital bone defects of the skull (an experimental and clinical study) -

The thesis analyses results of an experimental study using different plastic materials for the plasty of frontoorbital bone defects of the skull. Peculiarities of tissue responses around implants made of co-rundum ceramics, titanium, Protacryl-M, and corundum ceramics were examined with the plasty of thecal defects by formalinized homotransplant of the dura mater, Tachocomb wound cover. The expediency of corundum implants was experimentally grounded for the plasty of frontoorbital bone defects of the skull. It was revealed that spiral computed tomography was a highly effective technique for examining patients with frontoorbital bone defects of the skull, and it was absolutely indicated for the defects which spread below the anterior 1/3 part of the superior orbit wall. On the basis of the data of computed tomography of the head, a three-stage technique of computed-mathematical modeling of implants for the cranioplasty of frontoorbital bone defects of the skull was devised, thereby making it possible tocalculate parameters of inculcated in an implant in a semi-automatic mode, receive 3D visualization of the voluminal model of a bone defect, and form initial data for making an implant. A way of the plasty of frontoorbital bone defects of the skull was devised, experimentally grounded and introduced into practical neurosurgery; it includes preopera-tive computed-mathematical modeling of implants followed by cranioplasty with corundum implants. The analysis of neurosurgical treatment of 32 patients with frontoorbital bone defects of the skull, using co-rundum practical work of neurosurgical departments at many medical institutions of Ukraine.corundum implants and the technique of computed-mathematical modelling, was revealed positive dynam-ics of the patients' life quality within the close and remote periods following surgical treatment. It is shown that the way of cranioplasty of frontoorbital bone defects with use of corundum implants and the technique of computed-mathematical modeling makes it possible to perform germetic cranioplasty of cra-nial defects of complicated configuration and improve the level of social-labour rehabilitation. Results of dissertation was introduced in practice of neurosurgical department of Kharkov state clinical hospital, ІІ neurosurgical department of Kharkov city clinical hospital of fast and urgent medical help.