Shchebentovska O. Morphofunctional condition of immune system organs of rats and chickens under the influence of the solution of natrium hypochlorite during T-2 toxicosis

Object of research - change morphogenesis of immune system and pathogenesis of animals micotoxicosis. The purpose of research - to study path-morphology and morphogenesis changes in bodies of immune system of white rats and hens at experimental Т-2 toxicosis and influence of the solution of natrium hypochlorite (NHC) received on electrolyzer DEO-01-MEDEK (Russia) and highly-cleaned solution "Septoks". Methods of research - toxicological, clinic-anatomic, gematological, biochemical, immunological, histological, histochemical, electron-microscopic, morphometric, statistical. Scientific novelty of work: for the first time comparative research immunologic indicators that morpho-functional changes in bodies of immune system of rats and hens under influence of different concentration of solutions of "Septoks" and NHC is conducted at experimental chronic Т-2 toxicosis. It was studied morphogenesis of changes of thymus, spleens, lymph nodes of rats and bursa of Fabricius, thymus, spleens of hens at chronic Т-2toxicosis. The analysis of results of structurally functional changes in bodies of immune system under influence of different solutions NHC has allowed to prove scientifically a therapeutic dose with immunal-correcting effect at chronic Т-2 toxicosis. On the basis of the received results of use of solution NHC and "Septoks" for treatment of hens is proved at Т-2 toxicosis. It is offered: treatment of Т-2 toxicosis of poultry, by drinking solution "Septoks" in the concentration of 20 mg/l. It is inculcated: in an educational process at the study of discipline "Pathological anatomy of animals", scientific researches of Lviv national university of veterinary medicine and biotechnology under the name of S.Z. Gzhitskiy. There were developed and ratified technical terms by the chairman of the State department of veterinary medicine of Ukraine "Solution of sodium hypochlorite" (TT U 24.4-00485670-047-2004). As a result of researches methodical recommendations were published in a co-authorship. Field of application:veterinary medicine.