Mandryk S. Role of heat shock proteins in pathogenesis of gastric diseases

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0409U000502

Thesis Registration Form

0409U000502.pdf

Applicant for

Specialization

  • 03.00.04 - Біохімія

26-01-2009

Specialized Academic Board

Д 26.001.24

Taras Shevchenko National University of Kyiv

Essay

Heat shock proteins Hsp60, Hsp70 and Hsp90 level dynamic in gastric mucosa upon experimental chronic atrophic gastritis and stress-induced ulcer were investigated. It was established that shaperones level were increased on different stages of diseases development. Also the level of TBA-reactive substances, as well as catalase and superoxidedismutase activities and apoptotic protein Bax and proliferation marker Ki-67 levels were determed. It may be summarized that Hsp60, Hsp70 and Hsp90 take place in molecular mechanisms of cytoprotection. Beside that cell localization of Hsp70 and Hsp90 in human gastric adenocarcinoma cells was studied and compared with Hsp70 and Hsp90 cell localization of normal mucous cells.

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Files

Мандрик автореферат.doc

Мандрик дисертація.doc

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