Тkachenko T. Acid-base state and indices of mineral metabolism in organisms of pregnant rats and foetuses with lead poisoning.

The dissertation is devoted to the study of lead influence on acid-base state and indices of mineral metabolism in the organism of pregnant rats and foetuses. A biological model of lead acetate poisoning of rats against a background of pregnancy was elaborated and the indices of acid-base state, mineral, nitrogen and carbohydrate metabolism in the organisms of poisoned pregnant rats were also studied. It is noted that lead poisoning of pregnant rats leads to the increase of its contents in the blood, liver, kidneys, heart, spleen, muscles, bones, placenta, liver, foetuses and in the liver of rat foetuses. An increase of aspartataminotransferase, alanineaminotransferase, у-glutamyltransferase activity and increased concentration of glucose in the blood of lead poisoned pregnant and non-pregnant rats was found. It is noted that the introduction of lead acetate to rats causes displacement of acid-base state towards the metabolic acidosis, more evident in the organisms of poisoned pregnant rats. Multidirectional changes of sodium, potassium, magnesium, calcium, copper, iron and zinc contents in the blood, organs and fetoplacental complex of rats with lead poisoning were also established. It is mentioned that the introduction of calcium lactate to poisoned pregnant and non-pregnant rats is likely to decrease the lead contents in their organisms, and it can be used as an effective means of correction of lead poisoning.